Editing Transgenerational Epigenetic Inheritance (section)

=== The Dutch Hunger Winter ===
Human epidemiological data is difficult to parse, but the Dutch Famine of 1944-1945 provided a tragic natural experiment. Individuals who were conceived during the famine (F1) were born smaller and went on to suffer higher rates of obesity, schizophrenia, and cardiovascular disease as adults compared to siblings conceived before or after the famine. 

Modern genomic analysis of these individuals decades later revealed distinct differences in DNA methylation at key metabolic loci (such as the ''IGF2'' gene) compared to their unexposed siblings. While tracking this to the F3 generation in humans is statistically complex, it provides powerful evidence of long-lasting transcriptional memory induced by environmental trauma.